CHEMISTRY OF BIOCONJUGATES
Bioconjugation has enabled breakthroughs across many areas of industry and biomedicine. With its emphasis on synthesis, properties and applications, this book enables readers to understand the connection between chemistry and the biological application of bioconjugated materials. Its detailed
descriptions of methods make it possible for researchers to fabricate and take full advantage of bioconjugates for a broad range of applications. Moreover, the book sets the foundation for the development of new applications, including assays, imaging, biosensors, drug delivery, and diagnostics.
Chemistry of Bioconjugates features contributions from an international team of leading experts and pioneers in the field. These contributions reflect the authors’ firsthand laboratory experience as well as a thorough review of the current literature. The book’s six sections examine:
• General methods of bioconjugation
• Polymer bioconjugates
• Organic nanoparticle-based bioconjugates
• Inorganic nanomaterial bioconjugates, including metals and metal oxides
• Cell-based, hydrogel/microgel, and glyco-bioconjugates
• Characterization, physico-(bio)chemical properties, and applications of bioconjugates
This comprehensive exploration of bioconjugates includes discussions of polymers, dendrimers, lipids, nanoparticles, and nanotubes. References at the end of each chapter serve as a gateway to the most important original research findings and reviews in the field.
By drawing together and analyzing all the latest chemical methods and research findings on the physicochemical and biochemical properties of bioconjugates, Chemistry of Bioconjugates sheds new light on the significance and potential of bioconjugation. The book is recommended for organic and polymer chemists, biochemists, biomaterial scientists, carbohydrate chemists, biophysicists, bioengineers, and drug and gene delivery scientists.
POLYMERS AND NANOMATERIALS FOR GENE THERAPY
Gene Therapy has gained significant interest in the last few decades due to its potential for the treatment of several genetic diseases. Synthetic non-viral systems have emerged as the most promising systems for gene delivery and as such several polymers and nanomaterials have been carefully engineered to overcome several key challenges with these systems. Although remarkable progress have been made towards the most effective gene delivery systems, several challenges still exist which has significantly impacted the clinical translation of these materials. Therefore, the aim of this book is to provide an overview of the several polymeric and nanomaterials gene delivery systems developed so far. Besides, the engineering and choice of materials used, the book also discusses in detail the mechanism, the challenges and opportunities in gene therapy.
Overall, the book discusses the following topics:
Mechanism, current challenges and new approaches for non-viral gene delivery
Synthetic and Natural Polymers, Nanoparticles, Dendrimers for gene delivery
Gene therapies in clinical trials
Biochemical assays used for in vitro and in vivo gene expression
ENGINEERED CARBOHYDRATE-BASED MATERIALS FOR BIOMEDICAL APPLICATIONS
While carbohydrate-based materials are commonly used in numerous biomedical and biological applications, there is a paucity of systematic information on how best to approach the design, synthesis and characterization of such materials. This book provides a much-needed overview of the subject, focusing on synthesis and characterization techniques for several key biomaterials, including polymers, surfaces, dendrimers, nanoparticles and hydrogels.
Featuring contributed chapters written by experts in the field, this volume offers practical guidance on how to choose the appropriate synthetic approach for each material under discussion, clearly explaining their interactions with living organisms, their role in various biological processes, and their biomedical or biological applications. Coverage includes:
- Synthesis and self assembly of glycopolymers biomaterials and their role in tissue engineering, drug delivery, and non-invasive gene therapy
- The role of glycopolymer bioconjugates in biological assays, diagnostics and the study of carbohydrate-protein interactions
- The design and synthesis of biomacromolecules, including glycodendrimers, nanoparticles and hydrogels Biological and biomedical applications of nanoparticles in drug delivery, pathogen inhibition, MRI and others
- Hydrogel applications in tissue engineering, pathogen inhibition and drug delivery
This book provides comprehensive coverage of smart biomaterials and their potential applications, a field that is developing at a very rapid pace. Because smart biomaterials are an emerging class of biomaterials that respond to small changes in external stimuli with large discontinuous changes in their physical properties, they have been designed to act as an “on–off” switch for, among others, bio separation, immunoanalysis, drug delivery technologies, gene therapy, diagnostics, bio sensors and artificial muscles. After an introduction to the topic and the history of smart biomaterials, the author gives the reader an in-depth look at the properties, mechanics, and characterization of smart biomaterials including hydrogels, particles, assemblies, surfaces, fibers and conjugates. Information on the wide range of applications for these materials follows, including drug delivery, tissue engineering, diagnostics, biosensors, bio separation and actuators. In addition, recent advances in shape memory biomaterials as active components of medical devices are also presented.
GLYCOPOLYMERS: SYNTHESIS AND APPLICATIONS
lycopolymers have received considerable interest in recent years due to their increasing potential applications in material science and biomedicine. With better understanding of the role of carbohydrates in biological systems and with recent advances in organic and carbohydrate chemistry, the design and synthesis of glycopolymers have become simpler where significant research efforts have been carried out towards the fabrication of advanced glyco-polymeric architectures for improved performance.
This book provides an update on the recent advances on the synthesis of glycopolymers, their characterisations, their biological properties and their applications. The first objective of this book is to provide the readers a detailed overview about the synthesis of glycopolymers via several modern polymerisation techniques. The characterisation of these materials and their solution properties are also discussed. In addition to this, the conjugation of glycopolymers to different types of biomacromolecules are discussed. The second objective of this book is to provide the readers a detailed overview of the applications glycopolymers. In addition, the biological properties of the glycopolymers as a function of the types of carbohydrates attached, the polymer architectures and compositions are elaborated. This book will provide a quick reference to students and researchers working in both academia and industry.